Retrieve data from related entity

hiI read somewhere that it was not possible to fetch from the fields of an entity related to another by the mean of an intermediate entity.

For example I have an entity A (col1, col2), which is related to Entity B (col3, col4) which is related to Entity C (col5). Is it possible to have a Fetch a.col1 and C.col5?So what is the best way to do this?

best regard